منابع مشابه
Atypical Fibroxanthoma
Atypical fibroxanthoma (AFX) is a nodular dermal ulcerative lesion with a favorable prognosis. AFX most commonly occurs on sun-exposed skin in elderly individuals. AFX is characterized by its association with ultraviolet radiation, not only from a clinical aspect, but also from a molecular aspect. Making a diagnosis of AFX is challenging, and it is important to differentiate it from squamous ce...
متن کاملAtypical fibroxanthoma†
Atypical fibroxanthoma (AFX) is a rare skin neoplasm of low-grade malignancy and fibroblastic origin. AFX is a curable cutaneous disease and the diagnosis depends on knowledge of its clinical and histological features and combined immunohistochemistry markers. This study presents a case of a male patient, aged 90 years, presented with painless skin lesion in his ear. The lesion had been growing...
متن کاملAtypical Fibroxanthoma of the Eyelid
Atypical fibroxanthoma (AFX) is an uncommon, fibrohistiocytic tumor of the skin that occurs due to actinic damage in the elderly (1). AFX rarely affects eyelid (2). It appears as solitary nodule that smaller than 2 cm (3). Boynton was the first to describe a case of AFX involving the eyelid in the literature (2). Aggresive recurrence was reported in few AFX cases, despite the benign nature of t...
متن کاملGranular cell atypical fibroxanthoma.
We report on two patients with granular cell atypical fibroxanthoma. Both neoplasms were solitary, light-tan, dome-shaped papules on sun-exposed areas of the head in two elderly white men. Microscopically, these neoplasms showed a dermal proliferation of pleomorphic granular cells with irregular hyperchromatic nuclei, multinucleated cells, and scattered mitoses. Immunohistochemical stains were ...
متن کاملGenomic analysis of atypical fibroxanthoma
Atypical fibroxanthoma (AFX), is a rare type of skin cancer affecting older individuals with sun damaged skin. Since there is limited genomic information about AFX, our study seeks to improve the understanding of AFX through whole-exome and RNA sequencing of 8 matched tumor-normal samples. AFX is a highly mutated malignancy with recurrent mutations in a number of genes, including COL11A1, ERBB4...
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ژورنال
عنوان ژورنال: Cancer
سال: 1977
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197708)40:2<736::aid-cncr2820400222>3.0.co;2-p